C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C12N 5/10 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2670003
The present invention provides a prion protein (PrP)-free immortalized somatic human cell line wherein both alleles of the PrP gene have been completely deleted by homologous recombination. The invention further provides a method for the production of said cell line and its use for producing human recombinant proteins which are suitable as biopharmaceuticals.
La présente invention concerne une lignée cellulaire humaine somatique immortalisée exempte de protéine de prion (PrP), les deux allèles du gène PrP ayant été complètement délétés par recombinaison homologue. L'invention concerne en outre un procédé pour la production de ladite lignée cellulaire et son utilisation pour produire des protéines recombinantes humaines qui sont appropriées en tant que produits biopharmaceutiques.
Bjoernstrup Kim
Casademunt Elisabeth
Schroeder Carola
Borden Ladner Gervais Llp
Octagene Gmbh
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