C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2230654
Isolated nucleic acid molecules are provided encoding human PS1 gene products. Mutant PS1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of the activity of the PS1 polypeptide and mutants thereof. Also provided are diagnostic methods for detecting Alzheimer's disease and therapeutic methods for treating the same.
Molécules d'acide nucléique isolées qui codent des produits géniques PS1 humains. La présente invention concerne également des polypeptides PS1 mutants, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison pour produire lesdits polypeptides. Elle concerne en outre des procédés de détection destinés à identifier des agonistes et des antagonistes de l'activivité du polypeptide PS1 et de mutants dudit polypeptide. Elle concerne encore des procédés de diagnostic permettant de détecter la maladie d'Alzheimer et des méthodes thérapeutiques destinées à la traiter.
Tanzi Rudolph E.
Wasco Wilma
Mbm & Co.
The General Hospital Corporation
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