Genetic analysis of peyers's patches and m cells and methods...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) C12N 5/078 (2010.01)

Patent

CA 2443644

Methods of increasing of or decreasing the levels of a protein in a PP cell; methods of increasing antigen, vaccine, DNA vaccine delivery to M cells, use of human serum albumin and other transport enhancing proteins to enhance oral drug delivery; use of calreticulin to enhance oral antigen delivery, use of other cell surface proteins, receptors, and transporters to enhance delivery to M cells of antigens or vaccine delivery vehicles, use of other cytoplasmic proteins to regulate intracellular trafficking and delivery to mucosal immune sampling and processing systems.

L'invention concerne des procédés permettant d'augmenter et de réduire les taux de protéine dans une cellule PP. L'invention concerne également des procédés permettant d'augmenter un antigène, un vaccin, l'administration d'un vaccin ADN à des cellules M, l'utilisation d'albumine sérique humaine et d'autres protéines renforçant le transport, pour renforcer l'administration par voie orale de médicaments. L'invention concerne encore l'utilisation de calréticuline pour renforcer l'administration par voie orale d'un antigène, l'utilisation d'autres protéines, récepteurs et transporteurs de surface cellulaire, pour renforcer l'administration d'antigènes ou de véhicules d'administration de vaccin à des cellules M, l'utilisation d'autres protéines cytoplasmiques dans la régulation de la circulation intracellulaire et l'administration à des systèmes d'échantillonnage et de traitement immunitaires des muqueuses.

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