C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C07K 14/47 (2006.01) C12N 5/02 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2419851
This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subjet which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.
La présente invention concerne un procédé permettant de transformer une cellule embryonnaire en un neurone ventral. Ce procédé consiste à introduire dans la cellule embryonnaire un acide nucléique exprimant la protéine Nkx6.1 ou Nkx6.2 de facteur de transcription à homéodomaine dans la cellule embryonnaire, de manière à transformer la cellule embryonnaire en un neurone ventral. La présente invention concerne des méthodes permettant de diagnostiquer une maladie dégénérative du motoneurone chez un sujet. L'invention concerne également des méthodes permettant de traiter la dégénérescence neuronale chez un sujet, consistant à implanter, dans un tissu neural malade du sujet, une cellule embryonnaire neurale comprenant une molécule d'acide nucléique isolée pouvant exprimer la protéine Nkx6.1 ou Nkx6.2 à homéodomaine dans des conditions telles que la cellule embryonnaire est transformée en un motoneurone après implantation, ce qui permet de traiter la dégénérescence neuronale chez le sujet.
Briscoe James
Ericson Johan
Jessell Thomas M.
Rubenstein John L. R.
Sander Maike
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Regents Of The University Of California
The Trustees Of Columbia University In The City Of New York
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