C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/706 (2006.01) C12N 9/10 (2006.01)
Patent
CA 2195396
A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.
L'invention concerne un procédé de détection et de traitement de troubles cellulaires prolifératifs associés à l'expression de la glutathione-S-transférase (GSTP1). Le procédé consiste à détecter directement un promoteur de la GSTP1 hyperméthylée, ou à détecter indirectement la déplétion de l'ARNm de GSTP1 ou de la protéine de GSTP1 dans un échantillon tissulaire suspect.
Isaacs William B.
Lee Wen-Hsiang
Nelson William G.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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