C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2665678
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems.
L'invention concerne des paires orthogonales de synthétases d'ARNt et d'aminoacyle-ARNt pouvant incorporer des acides aminés non naturels dans des protéines de cellules hôtes de mammifère, par exemple, des cellules hôtes de primate et des cellules hôtes de rongeur. A titre d'exemple mais sans que cela ne soit limitatif, l'invention concerne également des systèmes de traduction qui comportent des cellules hôtes (par exemple des cellules de primate ou de rongeur), des synthétases d'aminoacyle-ARNt orthogonales dérivées de synthétases eubactériennes, des ARNt orthogonaux et l'acide aminé non naturel. L'invention concerne enfin des procédés de production de protéines d'intérêt comprenant au moins un acide aminé non naturel dans des systèmes de cellules hôtes de mammifère.
Liu Wenshe
Schultz Peter G.
Fetherstonhaugh & Co.
The Scripps Research Institute
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