Genetic markers associated with interferon-alpha response

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2761125

The present invention provides genetic markers on human chromosome 19 that are associated with a beneficial response to interferon alpha (IFN-a). These IFN-a response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment with IFN-a pharmaceutical compositions and drug products, in methods of treating patients having a disease susceptible to treatment with an IFN-a, and in methods for selecting the most appropriate therapy for such patients.

Cette invention concerne des marqueurs génétiques sur le chromosome humain 19 qui sont associés à une réponse positive à l'interféron alpha (IFN-a). Ces marqueurs de réponse à l'IFN-a sont utiles, inter alia, pour identifier les patients les plus susceptibles de bénéficier d'un traitement à base de compositions pharmaceutiques et de produits médicamenteux contenant de l'IFN-a, dans des méthodes de traitement de patients atteints d'une maladie susceptible d'être traitée avec un IFN-a, et dans les procédés de sélection de la thérapie la plus appropriée pour ces patients.

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