Genetic markers for obesity

Details Genetic markers for obesity Genetic markers for obesity

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2539624

The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1) >C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1) >A (allele 2); PLIN5: 13041A (allele 1) >G (allele 2) and PLIN6: 14995A (allele 1) >T (allele 2), and their use in diagnostic and prognostic applications for obesity and and obesity-related diseases, such as metabolic syndrome and cardiovascular disease.

L'invention concerne de nouvelles variantes génétiques ou de nouveaux polymorphismes génétiques au niveau du locus de la périlipine (<I>PLIN</I>) comprenant <I>PLIN1</I> : 6209T (allèle 1) >C (allèle 2) ; <I>PLIN3</I> 10171 (allèle 1) A>T (allèle 2) ; <I>PLIN4</I> : 11482G (allèle 1) >A (allèle 2) ; <I>PLIN5</I> : 13041A (allèle 1) >G (allèle 2) ET <I>PLIN6</I> : 14995A (allèle 1) >T (allèle 2), ainsi que leur utilisation dans des applications de diagnostic et de pronostic en matière d'obésité et de pathologies apparentées à l'obésité, comme le syndrome métabolique et les maladies cardio-vasculaires.

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