Genetic markers for predicting disease and treatment outcome

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2572384

The invention provides compositions and methods for determining the increased risk for recurrence of certain cancers and the likelihood of successful treatment with one or both of chemotherapy and radiation therapy. The methods comprise determining the type of genomic polymorphism present in a predetermined region of the gene of interest isolated from the subject or patient. Also provided are nucleic acid probes and kits for determining a patient's cancer risk and treatment response.

L'invention concerne des compositions et des procédés destinés à déterminer le risque accru de récurrence de certains cancers et la vraisemblance d'un traitement réussi avec la chimiothérapie ou la radiothérapie, ou les deux. Ces procédés consistent à déterminer le type de polymorphisme génomique présent dans une zone prédéfinie du gène d'intérêt isolé du sujet ou du patient. L'invention concerne également des sondes d'acides nucléiques et des nécessaires destinés à déterminer le risque de cancer d'un patient et sa réponse au traitement.

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