C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2753460
The invention relates to a method for determining an individual's risk of suffering from restenosis following the implant of a stent. The method is based on the analysis of a sample for determining the genotype in at least one single nucleotide polymorphism (SNP) selected from rs350099, rs350104, rs164390 and rs875459, in the CCNB1 gene, and optionally rs2282411 and/or rs733590 in the CCNA1 and CDKN1A genes, respectively, where the presence of certain alleles in any of said polymorphisms indicates the risk of suffering from restenosis.
La présente invention concerne une méthode pour déterminer le risque pour un sujet de présenter une resténose après l'implantation d'une endoprothèse. Ladite méthode est fondée sur l'analyse d'un échantillon pour déterminer le génotype dans au moins un polymorphisme de base unique (SNP) sélectionné parmi rs350099, rs350104, rs164390 et rs875459, dans le gène CCNB1, et, éventuellement de rs2282411 et/ou rs733590, dans les gènes CCNA1 et CDKN1A, respectivement; la présence d'allèles déterminés dans un desdits polymorphismes indiquant le risque de resténose.
Andres Garcia Vicente
Chaves Martinez Felipe Javier
Fernandez Aviles Francisco
Fernandez Ferri Patricia
Sanchez Fernandez Pedro Luis
Fina Biotech S.l.u.
Gowling Lafleur Henderson Llp
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