Genetic markers of toxicity, preparation and uses thereof

Details Genetic markers of toxicity, preparation and uses thereof Genetic markers of toxicity, preparation and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2380383

The invention concerns novel methods for determining the toxic potential of test compounds, as well as equipment and kits for implementing said methods. The invention also concerns methods for generating nucleic acid sequences for use as genetic markers of toxicity. The invention is based in particular on the constitution of differential libraries of nucleic acids, characteristic of situations wherein the viability and/or cell proliferation are disrupted, and for demonstrating that said libraries are useful for very dependably assessing with high degree of sensitivity the toxic profile of compounds. The invention is particularly useful in the pharmaceutical industry, for analysing the toxic profile of molecules to be used for pharmaceutical preparation and/or in pharmaceutical compositions.

La présente invention décrit de nouvelles méthodes permettant de déterminer le potentiel toxique de composés tests, ainsi que des outils et kits pour la mise en oeuvre de ces méthodes. L'invention décrit également des méthodes pour générer des séquences d'acides nucléiques utilisables comme marqueurs génétiques de la toxicité. L'invention repose notamment sur la constitution de banques différentielles d'acides nucléiques, caractéristiques de situations dans lesquelles la viabilité et/ou la prolifération cellulaire sont dérégulées, et dans la mise en évidence que ces banques sont utilisable pour évaluer avec une fiabilité et une sensibilité importante le profil toxique de composés. L'invention est particulièrement utile dans l'industrie pharmaceutique, pour l'analyse du profil toxique de molécules qui pourront entrer en développement pharmaceutique et/ou dans des compositions pharmaceutiques.

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