Genetic models for stratification of cancer risk

Details Genetic models for stratification of cancer risk Genetic models for stratification of cancer risk

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2656199

The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of selected genes, namely ACCalpha, ADPRT, CYPlAl, CYPlBl, GADD45, HLAh, 1CAM5, KLKlO, KLK2, MP0463, MSH6, PGR, RAD51L3, STK15 AND TFR, and particular combinations of genotypes, to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

La présente invention concerne de nouveaux procédés utilisables pour l'évaluation des risques de cancer dans la population générale. Ces procédés utilisent des allèles particuliers de gènes sélectionnés et des combinaisons particulières de génotypes afin d'identifier les individus présentant un risque accru ou diminué de cancer du sein. En outre, des valeurs faisant partie des antécédents personnels, telles que l'âge et la race, sont utilisées pour raffiner encore l'analyse. Grâce à ces procédés, il est possible de réallouer les dépenses médicales associées au dépistage du cancer en direction de sous-populations de patients souffrant d'un risque de cancer accru. Cela permet également d'identifier les candidats à l'administration d'un traitement prophylactique contre le cancer.

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