Genetic modification of endothelial cells

Details Genetic modification of endothelial cells Genetic modification of endothelial cells

C - Chemistry, Metallurgy

12

N

167/104, 167/327

C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 38/37 (2006.01) A61K 38/46 (2006.01) A61K 38/49 (2006.01) A61L 27/38 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 1340427

Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells. Such endothelial cells are useful in improving the performance of vascular grafts and in delivering the encoded polypeptide or protein, such as an enzyme, a hormone or a drug, to an individual who has had a graft or implant of the transduced cells.

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