Genetic modification of neural stem cells

Details Genetic modification of neural stem cells Genetic modification of neural stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 35/30 (2006.01) A61K 35/54 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07H 21/04 (2006.01) C12N 5/00 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) A61K 38/04 (2006.01) A61K 38/22 (2006.01) A61K 38/27 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2155024

Genetically modified, epidermal growth factor-responsive neural stem cells are disclosed that are capable of differentiating into neurons, astrocytes, and oligodendrocytes in vitro. The stem cells can be proliferated in vitro to result in large numbers of cells for use in transplantation to treat various neurological disorders. The stem cells can be obtained from a human or other animal, cultured in vitro in the presence of a growth factor and genetically modified with desired DNA using techniques known in the art. Alternatively, the precursor cells can be derived from a transgenic animal which has had a desired gene inserted into its genome.

L'invention concerne des cellules souches nerveuses sensibles aux facteurs de croissance épidermique, modifiées génétiquement, lesquelles sont capables d'une différentiation parmi les neurones, les astrocytes et les oligodendrocytes in vitro. On peut faire proliférer les cellules souches in vitro afin d'obtenir de grands nombres de cellules destinées à être utilisées dans la transplantation, afin de traiter divers troubles neurologiques. On peut obtenir les cellules souches à partir d'un sujet animal ou humain, les cultiver in vitro en présence d'un facteur de croissance, et les modifier génétiquement à l'aide des techniques de génie génétique voulues connues dans l'art. Dans un autre mode de réalisation, on peut dériver les cellules précurseurs à partir d'un animal transgénique dans le génome duquel on a inséré le gène voulu.

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