Genetic polymorphisms associated with alzheimer's disease,...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2626086

The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

La présente invention repose sur la découverte de polymorphismes génétiques qui sont associés à la maladie d'Alzheimer. La présente invention concerne plus précisément des molécules d'acide nucléique contenant ces polymorphismes, des variants protéiques codés par ces molécules d'acide nucléique, des réactifs destinés à la détection de ces molécules d'acide nucléique et protéines polymorphes, ainsi que des méthodes d'utilisation de ces molécules d'acide nucléique et ces protéines et des méthodes d'utilisation de réactifs pour leur détection.

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