Genetic polymorphisms associated with cardiovascular...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/47 (2006.01) C07H 21/04 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2613521

The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

La présente invention repose sur la découverte de polymorphismes génétiques qui sont associés à des troubles cardio-vasculaires, notamment à des accidents coronaires aigus tels que l'infarctus du myocarde et l'accident vasculaire cérébral, et à des polymorphismes qui sont associés à la sensibilité d'un sujet souffrant d'un trouble cardio-vasculaire au traitement du trouble avec de la statine. En particulier, la présente invention a trait à des molécules d'acide nucléique contenant les polymorphismes, à des protéines variantes codées par de telles molécules d'acide nucléique, à des réactifs permettant la détection de molécules d'acide nucléique et à des protéines polymorphes, et à des procédés d'utilisation de l'acide nucléique et des protéines ainsi qu'à des procédés d'utilisation de réactifs pour leur détection.

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