C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2547072
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
L'invention concerne la découverte de polymorphismes génétiques associés à des troubles cardiovasculaires, notamment des événements coronariens aigus, tels que l'infarctus du myocarde et l'accident cérébrovasculaire, et des polymorphisme qui sont associés à la réactivité d'une personne à un traitement de troubles cardiovasculaires par la statine. L'invention porte notamment sur des molécules d'acide nucléique contenant les polymorphismes, sur des protéines variantes codées par lesdites molécules d'acide nucléique, sur des réactifs pour la détection des molécules d'acide nucléique polymorphes, et sur des procédés d'utilisation des acide nucléique et protéines ainsi que sur des procédés d'utilisation de réactifs pour leur détection.
Cargill Michele
Devlin James J.
Iakoubova Olga
Kirchgessner Todd
Koustubh Ranade
Applera Corporation
Bristol-Myers Squibb Company
Celera Corporation
Fetherstonhaugh & Co.
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