C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2680024
The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
L'invention concerne des compositions et des procédés basés sur des polymorphismes génétiques associés à une coronaropathie (notamment l'infarctus du myocarde), à l'anévrisme/la dissection, et/ou à une réaction à un traitement médicamenteux, notamment un traitement aux statines. Cette invention concerne, par exemple, des molécules d'acide nucléique contenant ces polymorphismes, des protéines variantes codées par ces molécules d'acide nucléique, des réactifs destinés à détecter les molécules d'acide nucléique polymorphiques et les protéines variantes, et des procédés d'utilisation de ces molécules et de ces protéines, ainsi que des procédés d'utilisation de réactifs pour leur détection.
Devlin James
Iakoubova Olga
Rowland Charles
Tong Carmen
Celera Corporation
Fetherstonhaugh & Co.
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