C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2558458
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
L'invention est basée sur la découverte de polymorphismes génétiques qui sont associés à des maladies coronariennes, et en particulier MI, et à une réponse à un traitement médicamenteux. L'invention concerne notamment des molécules d'acide nucléique contenant les polymorphismes, des protéines variants codés par de telles molécules d'acide nucléique, des réactifs permettant la détection de molécules d'acide nucléique et de protéines polymorphiques. L'invention concerne en outre des procédés d'utilisation d'acide nucléique et de protéines, ainsi que des procédés d'utilisation de réactifs permettant leur détection.
Cargill Michele
Devlin James
Shiffman Dov
Applera Corporation
Celera Corporation
Fetherstonhaugh & Co.
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