Genetic polymorphisms associated with coronary heart...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2600794

The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease and in particular stenosis and MI and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

La présente invention se rapporte à la découverte de polymorphismes génétiques associés à des maladies cardiaques coronariennes, et en particulier à la sténose et à l'IM, et à la réaction à un traitement médicamenteux. La présente invention concerne en particulier des molécules d'acide nucléique contenant les polymorphismes; des protéines variantes codées par lesdites molécules d'acide nucléique; des réactifs pouvant détecter les molécules d'acide nucléique polymorphiques et les protéines; et des méthodes d'utilisation de l'acide nucléique et des protéines. Elle concerne en outre des méthodes d'utilisation de réactifs pour détecter les molécules d'acide nucléique et les protéines.

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