C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2649920
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, specifically MI and including early-onset MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
La présente invention concerne la découverte de polymorphismes génétiques associés à la maladie coronarienne, en particulier au MI et notamment au MI précoce, et la réaction à un traitement médicamenteux. Plus spécifiquement, la présente invention concerne des molécules d'acide nucléique contenant lesdits polymorphismes, des protéines variantes encodées par lesdites molécules d'acide nucléique, des réactifs pour la détection des molécules d'acide nucléique polymorphes et des protéines, des procédés d'emploi des molécules d'acide nucléique et des protéines et des procédés d'emploi des réactifs pour la détection de ces dernières.
Devlin James J.
Shiffman Dov
Celera Corporation
Fetherstonhaugh & Co.
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