C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2716368
The present invention is based on the discovery of genetic polymorphisms that are associated with stroke and relat-ed pathologies, such as other vascular diseases. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
L'invention repose sur la découverte de polymorphismes génétiques associés à l'accident vasculaire cérébral et à des pathalogies connexes, telles que d'autres maladies vasculaires. L'invention concerne, en particulier, des molécules d'acides nucléiques contenant lesdits polymorphismes, y compris des groupes de molécules d'acide nucléique qui peuvent être utilisés comme un ensemble de marqueurs de signature, par exemple un haplotype, un diplotype, des protéines variantes codées par lesdites molécules d'acide nucléique, et des réactifs permettant de détecter les protéines et les molécules d'acides nucléiques polymorphiques. L'invention se rapporte également à des procédés d'utilisation de l'acide nucléique et des protéines, et à des procédés d'utilisation des réactifs afin de détecter ces derniers.
Devlin James
Luke May
Celera Corporation
Fetherstonhaugh & Co.
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