C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2566257
The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases and in particular coronary artery disease and stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
L'invention est basée sur la découverte de polymorphismes génétiques qui sont associés à des maladies vasculaires et notamment les maladies coronariennes et la sténose. Plus particulièrement, cette invention concerne des molécules d'acide nucléique contenant lesdits polymorphismes, des protéines variantes codées par ces molécules d'acides nucléiques, des réactifs destinés à détecter des protéines et des molécules d'acides nucléiques polymorphiques. L'invention concerne également des procédés d'utilisation desdites protéines et de l'acide nucléique ainsi que des procédés d'utilisation des réactifs dans la détection de polymorphismes génétiques.
Cargill Michele
Devlin James
Luke May
Applera Corporation
Celera Corporation
Fetherstonhaugh & Co.
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