Genetic selection, by means of signal transduction in...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/00 (2006.01) C07K 14/28 (2006.01) C07K 16/44 (2006.01) C12N 1/20 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2125536

Abstract of the disclosure Genetic selection, by means of signal transduction in microorganisms, of proteins which are capable of ligand binding The invention relates to a process for the genetic selection in microorganisms of proteins which are capable of ligand binding, in which process a protein which is capable of ligand binding is presented extra- cytoplasmically and the signal of the ligand binding is passed on by signal transduction to the biosynthetic machinery of the microorganism for the purpose of ex- pressing a detectable and/or selectable function. In addition to this, the patent discloses microorganisms which are suitable for use in this process, as well as replicons and processes for their preparation.

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