C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 15/113 (2010.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) C12N 15/864 (2006.01)
Patent
CA 2683469
The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
L'invention concerne la suppression et le remplacement de gènes. L'invention concerne notamment l'expression accrue d'agents de suppression destinés à supprimer l'expression d'un gène dans une cellule et in vivo et des acides nucléiques de remplacement qui ne sont pas inhibés par l'agent de suppression. Des éléments de régulation sont inclus dans les vecteurs d'expression afin d'optimiser l'expression de l'agent de suppression et/ou de l'acide nucléique de remplacement.
Chadderton Naomi
Farrar Gwyneth Jane
Humphries Peter
Kenna Paul
Millington-Ward Sophia
Fetherstonhaugh & Co.
The Provost Fellows And Scholars Of The College Of The Holy And Undivid Ed T
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