Genetic susceptibility variants associated with...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2679581

The invention relates to methods of diagnosing susceptibility to cardivascular disease, including coronary artery disease, MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.

La présente invention concerne des méthodes de diagnostic de la prédisposition aux maladies cardiovasculaires, y compris la coronaropathie, l'infarctus du myocarde, l'anévrisme de l'aorte abdominale, la resténose de l'anévrisme intracrânien et la maladie artérielle périphérique. Ces méthodes de diagnostic consistent à évaluer la présence ou l'absence d'allèles de certains marqueurs polymorphes qui se trouvent être associés aux maladies cardiovasculaires. Cette invention porte également sur des trousses comprenant des réactifs utiles pour évaluer lesdits marqueurs, sur des méthodes d'évaluation de la probabilité de réponse à des agents thérapeutiques et sur des méthodes dans lesquelles on utilise lesdits marqueurs.

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