Genetic test for the identification of carriers of complex...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2429275

Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at position 559 of the bovine SLC35A3 gene is identified as being causative and diagnostic for CVM in cattle.

L'invention concerne des marqueurs génétiques pour identifier les porteurs bovins du gène de malformation vertébrale complexe (MVC). Les marqueurs génétiques, y compris les marqueurs microsatellites BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 et BMS1266, ainsi que le gène bovin <i>SLC35A3</i> sont localisés sur le chromosome bovin BTA3. Le polymorphisme G/T en position 559 du gène bovin <i>SLC35A3</i> est identifié comme la cause et le diagnostic de MVC chez le bétail.

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