Genetic units for inhibiting the function of rna

Details Genetic units for inhibiting the function of rna Genetic units for inhibiting the function of rna

C - Chemistry, Metallurgy

12

N

167/202, 195/1.1

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2012312

A genetic unit, for inhibiting RNA contains the transcription units necessary for transcription by polymerase III and a DNA coding for inhibiting RNA, which is arranged within the unit in such a way that the transcribed RNA is part of the polymerase III transcript. Using these units it is possible to achieve increased stability of the inhibiting RNA, which may occur in the form of ribozymes or antisense-RNAs, whilst maintaining an undiminished activity. A process for introducing the genetic units into the cell, the use of these units and pharmaceutical preparations containing them are also disclosed.

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