Genetic vaccine vector engineering

Details Genetic vaccine vector engineering Genetic vaccine vector engineering

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C07K 14/16 (2006.01) C07K 14/24 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2320626

This invention provides methods of obtaining genetic vaccines by use of DNA shuffling. Through use of the claimed methods, vectors can be obtained which exhibit efficacy for use as genetic vaccines. Vectors obtained by using the methods can have, for example, enhanced antigen expression, increased uptake into a cell, increased stability in a cell, ability to tailor an immune response, and the like.

L'invention concerne des techniques permettant d'obtenir des vaccins génétiques à l'aide d'un réarrangement d'ADN. On peut, grâce à ces techniques, obtenir des vecteurs qui présentent une efficacité accrue, pouvant être utilisés comme vaccins génétiques. Ces techniques permettent également d'obtenir des vecteurs présentant, par exemple, une expression antigénique améliorée, une pénétration cellulaire accrue, une stabilité cellulaire augmentée, une aptitude à personnaliser une réponse immunitaire, etc.

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