C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/02 (2006.01) A23L 1/32 (2006.01) A61K 31/7088 (2006.01) A61K 39/108 (2006.01) A61K 39/39 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 14/245 (2006.01) C07K 16/12 (2006.01)
Patent
CA 2395840
Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenic Escherichia coli (ETEC) strains is disclosed. Additionally, plasmids may consist of multiple copies of the same antigen (i.e. K88 or K99 fimbrial antigen) or multiple antigens (i.e. K88 and K99 fimbrial antigens) and genetic adjuvants such as cytokines (IL-2, IL-4 & GM- CSF), costimulatory molecules (CD80 & CD86) or chemokines or immunostimulatory sequences. A method for isolating antibodies from chicken egg yolk for passive immunization of animals as well as humans to control diarrhoeal diseases using the genetic vaccines is also disclosed.
L'invention concerne un vaccin génétique qui comporte un ou plusieurs plasmides contenant des gènes qui codent pour des antigènes de souches d'Escherichia coli entérotoxinogène (ETEC). De plus, les plasmides peuvent être constitués de multiples copies du même antigène (c.-à-d. l'antigène fimbrial K88 ou K99) ou de multiples antigènes (c.-à-d. les antigènes fimbriaux K88 et K99), et d'adjuvants génétiques tels que des cytokines (IL-2, IL-4 et GM-CSF), de molécules costimulatrices (CD80 et CD86), de chimiomokines ou de séquences immunostimulatrices. L'invention concerne aussi un procédé permettant d'isoler des anticorps de jaune d'oeuf de poule à des fins d'immunisation passive d'animaux et d'êtres humains, pour lutter contre des maladies diarrhéiques au moyen des vaccins génétiques.
Cho Suk-Hyeon
Loewen Peter
Madhyastha Srinivasa
Marquardt Ronald
Battison Williams Dupuis
The University Of Manitoba
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