Genetic variants in the tcf7l2 gene as diagnostic markers...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2612475

Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.

Selon l'invention, les polymorphismes dans le gène TCF7L2 se révèlent être, par une analyse d'association, un gène de susceptibilité pour le diabète de type II. L'invention concerne des méthodes de diagnostic de la susceptibilité au diabète et d'une susceptibilité au diabète réduite ainsi que des méthodes de protection contre le diabète. L'invention concerne également des méthodes de traitement du diabète de type II.

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