Genetic variants predicting warfarin sensitivity

Details Genetic variants predicting warfarin sensitivity Genetic variants predicting warfarin sensitivity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2591840

We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the inter~individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

L'invention concerne un polymorphisme dans le promoteur du gène VKORCI présentant une sensibilité à la warfarine. Ledit polymorphisme peut expliquer les différences à la fois interindividuels et interéthniques dans les exigences de dosage de la warfarine. De plus, le polymorphisme est également associé à l'activité des promoteurs. De plus, la séquence ou l'activité des promoteurs du gène VKORCI d'un sujet peut être utilisé pour prévoir le moment auquel la warfarine doit être prescrite au sujet. L'invention concerne également des procédés et des compositions.

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