C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C07K 14/11 (2006.01) C12N 9/24 (2006.01)
Patent
CA 2118234
2118234 9321306 PCTABS00027 The present invention relates to engineering attenuated viruses by altering a non-coding region or the coding sequence of a viral gene. Alterations of the non-coding regions which regulate transcription and/or replication are described. These alterations result in the down-regulation of the viral gene and an attenuation of the virus, either by the production of defective particles during replication, or by reducing the number of progeny virions produced during viral replication. Alterations of viral coding sequences are also described which result in a recombinant or chimeric attenuated virus.
Osler Hoskin & Harcourt Llp
The Mount Sinai School Of Medicine Of The City University Of New
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