Genetically engineered canary poxvirus-based vaccine strain

Details Genetically engineered canary poxvirus-based vaccine strain Genetically engineered canary poxvirus-based vaccine strain

C - Chemistry, Metallurgy

12

N

C12N 15/863 (2006.01) A61K 39/12 (2006.01) A61K 39/275 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2558659

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant canary poxvirus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.

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