A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) C07K 14/51 (2006.01) C12N 5/10 (2006.01) C07K 14/71 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2301882
The present invention describes methods of producing cell lines which express recombinant DNA encoding bone morphogenetic proteins (BMP). The cell lines are capable of being implanted in order to enhance the regeneration of tissues through both autocrine and paracrine effects. The cells may further contain DNA encoding receptor proteins which are able to bind to BMPs or enhance or regulate BMP activity.
La présente invention traite de procédés de production de lignées cellulaires qui expriment de l'ADN recombinant codant des protéines morphogénétiques d'os (BMP). Ces lignées cellulaires sont susceptibles d'être implantées dans le but d'accroître la régénération de tissus grâce à des effets à la fois autocrines et paracrines. Ces cellules peuvent en outre renfermer de l'ADN codant des protéines réceptrices qui sont susceptibles de se fixer aux BMP ou d'accroître ou réguler leur activité.
Gazit Dan
Moutsatsos Ioannis
Turgeman Gadi
Zilberman Yoram
Genetics Institute Inc.
Genetics Institute Llc
Gowling Lafleur Henderson Llp
Yissum Research Development Company Of The Hebrew University Of
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