Genetically engineered fowlpox-based vaccine strain

Details Genetically engineered fowlpox-based vaccine strain Genetically engineered fowlpox-based vaccine strain

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12N 15/39 (2006.01) C12N 15/44 (2006.01) C12N 15/45 (2006.01) C12N 15/49 (2006.01)

Patent

CA 2621088

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant canary poxvirus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.

L'invention décrite concerne un vecteur modifié, par exemple un poxvirus recombinant, en particulier le poxvirus recombinant du canari, ayant une innocuité accrue. Comme on a inactivé des fonctions génétiques codées non essentielles du virus recombinant modifié, sa virulence est atténuée. Dans l'une des réalisations, les fonctions génétiques ont été inactivées par une délétion du cadre de lecture ouvert codant un facteur de virulence. Dans une autre réalisation, les fonctions génétiques ont été inactivées par une insertion inactivant un cadre de lecture ouvert codant un facteur de virulence. L'invention décrite porte aussi sur un vaccin contenant le virus recombinant modifié dont des fonctions génétiques codées non essentielles ont été inactivées, ce qui confère au vaccin une plus grande innocuité comparativement aux vaccins à base de virus recombinants connus.

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