C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/50 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) C12N 1/21 (2006.01) C12N 9/80 (2006.01) C12N 15/72 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2149922
Image DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and coloncancer cells and in the treatment of HIV-infected cells.
Freeman Abbie G.
Macallister Thomas W.
Roberts Joseph
Sethuraman Natarajan
Medical Enzymes Ag
Roberts Joseph
Sim & Mcburney
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