C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2430341
The present invention provides methods of expressing a nucleic acid or producing a proteinaceous composition encoded by a nucleic acid in vascular and cardiovascular cells by administration of a herpesvirus vector. The present invention provides methods of producing a therapeutic benefit in vascular and cardiovascular tissue by administration of a herpesvirus vector. In additional aspects, the invention concerns combination therapies for vascular and cardiovascular diseases comprising administration of a herpesvirus vector and treatment with at least addition pharmacological agent or surgical procedure.
La présente invention concerne des procédés permettant d'obtenir dans des cellules vasculaires et cardio-vasculaires, par administration d'un vecteur d'herpèsvirus, l'expression d'acide nucléique ou la production d'une composition protéinique codée par un acide nucléique. L'invention concerne plus particulièrement des procédés permettant d'obtenir des bienfaits thérapeutiques dans les tissus vasculaires et cardio-vasculaires, par administration d'un vecteur d'herpèsvirus. Par d'autres aspects, l'invention concerne des thérapies combinées destinées à des affections vasculaires et cardio-vasculaires, et consistant en l'administration d'un vecteur d'herpèsvirus accompagnée d'un traitement utilisant un autre agent pharmacologique ou une procédure chirurgicale.
Roizman Bernard
Schwartz Lewis B.
Weichselbaum Ralph R.
Finlayson & Singlehurst
The University Of Chicago
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