Genetically engineered human cholinesterases

Details Genetically engineered human cholinesterases Genetically engineered human cholinesterases

C - Chemistry, Metallurgy

12

N

530/13, 167/44,

C12N 15/55 (2006.01) A61K 38/46 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/18 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2012720

ABSTRACT The invention relates to genetically engineered human acetylcholinesterase (AChE). The invention provides for a DNA sequence encoding for the complete human AChE. The invention further relates to pharmaceutical compositions comprising AChE or biologically active essential fragments thereof for treatment and prophylaxis of organophosphorous compounds poisoning. In a further aspect the invention relates to human cholinesterases probes which may be employed for diagnosing progressing ovarian carcinomas and hemocytopoistic disorders. Methods of diagnosing and treating such tumors and hemocytopoietic disorders are also envisaged.

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