C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2261026
This invention deals with genetically engineered immunoglobulins with affinity and specificity for (human) glycated albumin. The invention is directed to the DNA which encodes the immunoglobulins. The DNA sequence can be manipulated to produce chimeras and fragments such as Fab, F(ab')2 or ScFv. The immunoglobulins can be produced by recombinant DNA methods and readily purified. The invention also provides a novel and improved method for treating the complications of diabetes.
La présente invention concerne des immunoglobulines obtenues par génie génétique présentant une affinité et une spécificité vis-à-vis de l'albumine (humaine) glycolysée. L'invention porte sur l'ADN codant les immunoglobulines. La séquence d'ADN peut être manipulée pour produire des chimères et des fragments tels que Fab, F (ab')¿2? ou ScFv. On peut produire lesdites immunoglobulines par des méthodes d'ADN recombiné et les purifier facilement. L'invention décrit aussi une méthode nouvelle et plus efficace de traitement des complications diabétiques.
Cohen Margo P.
Shearman Clyde W.
Blake Cassels & Graydon Llp
Exocell Inc.
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