C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2140354
2140354 9426100 PCTABS00034 The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.
Chambon Pierre
Dierich Andree
Gorry Philippe
Kastner Philippe
Lemeur Marianne
Centre National de La Recherche Scientifique
E. R. Squibb & Sons Inc.
E.r. Squibb & Sons Inc.
Gowling Lafleur Henderson Llp
Institut National de La Sante Et de La Recherche Medicale
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