C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01K 67/027 (2006.01) C07K 14/74 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01) G01N 33/554 (2006.01)
Patent
CA 2099001
2099001 9211753 PCTABS00014 The present invention provides mice which are deficient in the normal expression of one or more MHC class II genes, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous, homozygous or chimeric for such deficiency, as well as to the use of any of the above, especially in situations where the absence of at least one MHC gene, or the normal expression thereof, is desirable.
Benoist Christophe
Cosgrove Dominic
Mathis Diane
Centre National de La Recherche Scientifique (c.n.r.s.)
E.r. Squibb & Sons Inc.
Gowling Lafleur Henderson Llp
Institut National de La Sante Et de La Recherche Medicale
Universite Louis Pasteur Strasbourg I.
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