C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/04 (2006.01) C12M 1/40 (2006.01) C12N 15/10 (2006.01) C12N 15/53 (2006.01) C12Q 1/32 (2006.01) G01N 33/66 (2006.01)
Patent
CA 2570593
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, to genes encoding such variant s~GDH, to proteins of such s-GDH variants with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugars, especially of glucose in a sample.
L'invention porte sur des variants améliorés de glucose dehydrogenases (s-GDH) dépendant de pyrroloquinoline quinone (PQQ) solubles, comprenant une insertion d'acide aminé entre les positions 428 et 429 correspondant à la séquence d'acide aminé connue à partir de Acinetobacter calcoaceticus, sur le codage génique du variant s-GDH, sur des protéines des variants s-GDH possédant une spécificité de substrat au glucose améliorée, sur différentes applications de ces variants s-GDH, notamment afin de déterminer des concentrations de sucres, notamment de glucose dans un échantillon.
Boenitz-Dulat Mara
Knappe Wolfgang-Reinhold
Kratzsch Peter
Laggerbauer Jessica
Schmuck Rainer
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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