Genetically engineered vaccine strain

Details Genetically engineered vaccine strain Genetically engineered vaccine strain

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/12 (2006.01) C07K 14/015 (2006.01) C07K 14/02 (2006.01) C07K 14/03 (2006.01) C07K 14/035 (2006.01) C07K 14/045 (2006.01) C07K 14/05 (2006.01) C07K 14/06 (2006.01) C07K 14/065 (2006.01) C07K 14/07 (2006.01) C07K 14/11 (2006.01) C07K 14/12 (2006.01) C07K 14/125 (2006.01) C07K 14/145 (2006.01) C07K 14/15 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/175 (2006.01) C07K 14/18 (2006.01) C07K 14/33 (2006.01) C12N 7/01 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2105277

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to knwon recombinant virus vaccines.

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