C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12N 1/21 (2006.01) C12P 17/08 (2006.01)
Patent
CA 2608841
A genetically modified microorganism capable of directly producing a 16- hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium.
Microorganisme génétiquement modifié capable de produire directement un composé macrolide 16-hydroxylé ; et procédé pour produire un composé macrolide 16-hydroxylé en utilisant le microorganisme. Spécifiquement, l~invention concerne des microorganismes génétiquement modifiés ayant un ADN codant pour un polypeptide impliqué dans la biosynthèse d~un composé macrolide pladiénolide et un ADN codant pour un polypeptide ayant une activité de 16-hydroxylase pladiénolide ; et un procédé pour produire un composé macrolide 16-hydroxylé comprenant les étapes de culture du microorganisme génétiquement modifié dans un milieu de culture et de récolte d~un composé macrolide 16-hydroxylé à partir du milieu de culture.
Aritoku Yasuhide
Machida Kazuhiro
Eisai R&d Management Co. Ltd.
Mercian Corporation
Smart & Biggar
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