C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2663052
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid sulfotyrosine and translation systems.
L'invention concerne des paires orthogonales d'ARNt et des synthétases d'aminoacyle-ARNt pouvant intégrer l'acide aminé non naturel de sulfotyrosine dans des protéines produites dans des cellules hôtes eubactériennes telles que E.coli. L'invention concerne notamment mais pas exclusivement de nouvelles synthétases orthogonales amynoacyl-ARNt, des polynucléotides codant les nouvelles molécules de synthétase, des procédés d'identification et de préparation des nouvelles synthétases, des méthodes de production des protéines contenant des acides aminés non naturels et des systèmes de translation.
Liu Chang C.
Schultz Peter G.
Fetherstonhaugh & Co.
The Scripps Research Institute
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