C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2632419
It has been demanded to develop an antibody capable of binding to a polypeptide encoded by a human PERP (p53 apoptosis effector related to PMP-22) gene which is believed to be involved in the development of cancer or the like. Thus, disclosed is a genetically recombinant antibody which has a variable region bearing no consensus sequence to which an N-binding sugar chain can be bound, can recognize specifically the conformation of an extracellular region of a polypeptide encoded by the PERP gene, and can bind to the extracellular region. The antibody is useful for the treatment of various diseases in which a polypeptide encoded by the PERP gene is expresses.
L'invention concerne un anticorps capable de lier un polypeptide codé par un gène PERP humain (effecteur de l'apoptose par p53 apparenté au PMP-22) dont on pense qu'il est impliqué dans le développement du cancer ou similaire. Ainsi, l'invention concerne un anticorps génétiquement recombiné lequel a une région variable ne portant pas de séquence consensus à laquelle une chaîne de sucre liante en N peut être liée, peut reconnaître spécifiquement la conformation d'une région extracellulaire d'un polypeptide codé par le gène PERP et peut se lier à la région extracellulaire. L'anticorps est utile pour le traitement de différentes maladies dans lesquelles un polypeptide codé par le gène PERP est exprimé.
Furuya Akiko
Hosaka Emi
Nakamura Kazuyasu
Ochiai Atsushi
Ohki Yuji
Furuya Akiko
Goudreau Gage Dubuc
Hosaka Emi
Japan As Represented By President Of National Cancer Center
Kyowa Hakko Kogyo Co. Ltd.
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