Genome editing in rats using zinc-finger nucleases

Details Genome editing in rats using zinc-finger nucleases Genome editing in rats using zinc-finger nucleases

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A01K 67/027 (2006.01)

Patent

CA 2745031

Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

L'invention concerne des procédés et des compositions d'édition d'un génome d'un ou plusieurs sites chez un rat, par utilisation de protéines de fusion renfermant une protéine en doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. L'invention concerne également les polynucléotides encodant lesdites protéines de fusion ainsi que les cellules renfermant lesdits polynucléotides et lesdites protéines de fusion.

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