Genomes participating in rheumatoid arthritis, method of the...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2426765

A mutation in genomes participating in rheumatoid arthritis (RA) is found out in human DR3 genomic DNA having the base sequence represented by SEQ ID NO:1. Genomes having the above mutation, transcriptional products thereof, a method of highly accurately determining the RA onset possibility by using the mutation thereof, a determination kit therefor, and a therapeutic method and remedies for RA are provided.

Une mutation dans des génomes participant à l'arthrite rhumatoïde (AR) est identifiée dans l'ADN génomique humain DR3 doté de la séquence de base représentée par SEQ ID No: 1. L'invention concerne les génomes présentant la mutation précitée, des produits transcriptionnels de ces derniers, un procédé permettant de déterminer avec précision la possibilité d'apparition de l'AR au moyen de la mutation de cette dernière, un kit de détermination ad hoc et une méthode et des remèdes thérapeutiques destinés à l'AR.

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