Genomic analysis method

Details Genomic analysis method Genomic analysis method

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2360929

A method of comparing genomic DNA from two individuals who share a phenotype, cutting the DNA into fragments long enough to contain on average one or several polymorphisms; combining the fragments under hybridisation conditions and recovering mismatch-free heterohybrids, wherein adapters resistant to nuclease digestion are ligated to the ends of the genomic fragments. A related method uses pooled genomic DNA from individuals with a common phenotype. Another related method uses restricted nucleic acid fragments likely to contain on average less than one natural polymorphism.

L'invention concerne une technique de comparaison de l'ADN génomique de deux individus qui partagent un phénotype. Cette technique consiste à: couper l'ADN en fragments assez longs pour contenir en moyenne un ou plusieurs polymorphismes; combiner les fragments dans des conditions d'hybridation et récupérer les hétérohybrides exempts de mésappariement, les adaptateurs résistant à la digestion des nucléases étant ligaturés aux extrémités des fragments génomiques. Une technique apparentée utilise des ADN génomiques groupés d'individus possédant un phénotype commun. Une autre technique apparentée utilise des fragments d'acides nucléiques de restriction susceptibles de contenir en moyenne moins d'un polymorphisme naturel.

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